Might essential thrombocythemia carry Ph anomaly?
نویسندگان
چکیده
منابع مشابه
Cladribine as monotherapy or combined with dexamethasone and idarubicin or mitoxantrone in previously treated patients with low-grade lymphoid malignancies.
Haematologica vol. 85(2):February 2000 mia. Cancer Genet Cytogenet 1981; 4:138-42. 4. Knapp RH, Dewald GW, Pierre RV. Cytogenetic studies in 174 consecutive patients with preleukemic or myelodysplastic syndromes. Mayo Clin Proc 1985; 60: 507-16. 5. Mertens F, Johansson B, Heim S, Kristofferson U, Mitelman F. Karyotypic patterns in chronic myeloproliferative disorders: report on 74 cases and rev...
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According to the World Health Organization (WHO) 2008 criteria, MPNs are now divided in classical MPNs which carry the Philadelphia (Ph+) chromosome (chronic myeloid leukaemia) and classical MPNs which do not carry the Philadelphia (Ph-) chromosome, including essential thrombocythemia, polycythemia vera, primary myelofibrosis, chronic neutrophilic leukemia, chronic eosinophilic leukemia, mastoc...
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One of the diagnostic criteria of essential thrombocythemia laboratory characteristics, except for a significant increased patients’ age and decreased polymorphonuclear cell count (ET) is the absence of the Philadelphia chromosome (Phneg). On the molecular level, Ph-neg ET patients may carry in the BCR-ABL positive group. During a median follow-up of 20 and 22.5 months for the BCR-ABL negative ...
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The JAK2 V617F mutation has been observed in patients with Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-MPNs), including polycythemia vera, essential thrombocythemia and idiopathic myelofibrosis. This mutation has also been observed in a small number of other myeloid malignancies, such as acute myeloid leukemia, chronic myeloid leukemia and myelodysplastic syndrome. The JAK...
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Patients with essential thrombocythemia may carry JAK2 (V617F), an MPL substitution, or a calreticulin gene (CALR) mutation. We studied biologic and clinical features of essential thrombocythemia according to JAK2 or CALR mutation status and in relation to those of polycythemia vera. The mutant allele burden was lower in JAK2-mutated than in CALR-mutated essential thrombocythemia. Patients with...
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ورودعنوان ژورنال:
- Blood
دوره 91 8 شماره
صفحات -
تاریخ انتشار 1998